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src-selective kinase inhibitor pp1  (Merck KGaA)

 
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    Merck KGaA src-selective kinase inhibitor pp1
    Src Selective Kinase Inhibitor Pp1, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/src-selective+kinase+inhibitor+pp1/src+selective+kinase+inhibitor+pp1/pm26063313-38-17-24
    Average 90 stars, based on 1 article reviews
    src-selective kinase inhibitor pp1 - by Bioz Stars, 2026-09
    90/100 stars

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    other:

    Article Title: Anti-tumor peptide AP25 decreases cyclin D1 expression and inhibits MGC-803 proliferation via phospho-extracellular signal-regulated kinase-, Src-, c-Jun N-terminal kinase- and phosphoinositide 3-kinase-associated pathways.
    Article Snippet: The chemical inhibitors of key enzymes in various signaling pathways used in the present study included the Src-selective kinase inhibitor PP1 (cat no. 567809; Merck, Darmstadt, Germany), the PI3K inhibitor wortmannin (cat no. BML-ST415-0001; Biomol, Plymouth Meeting, PA, USA) and the JNK‐specific inhibitor SP600125 (cat no. EI-305-0010; Biomol).



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    Image Search Results


    UM1 (06-12) and Mel270 treatment with Src inhibitors (PP1/PP2) identified eight substrates with a significant reduction in phosphorylation ( A ). The inhibition of EFS peptide phosphorylation by genetic (Src siRNA) and pharmacological means (PP1) in cell line Mel270, and PP1 treatment of cell lysates of UM (UM1) and metastasis tissue (MET3) ( B ).

    Journal: British Journal of Cancer

    Article Title: Episodic Src activation in uveal melanoma revealed by kinase activity profiling

    doi: 10.1038/sj.bjc.6605172

    Figure Lengend Snippet: UM1 (06-12) and Mel270 treatment with Src inhibitors (PP1/PP2) identified eight substrates with a significant reduction in phosphorylation ( A ). The inhibition of EFS peptide phosphorylation by genetic (Src siRNA) and pharmacological means (PP1) in cell line Mel270, and PP1 treatment of cell lysates of UM (UM1) and metastasis tissue (MET3) ( B ).

    Article Snippet: Blocking experiments were carried out with Src family-selective tyrosine kinase inhibitors, PP1, PP2 (Biomol International, LP, of Plymouth Meeting, PA, USA) and PP3 (the inactive analogue, Calbiochem), at an end concentration of 10 μ M in line with a large body of literature.

    Techniques: Phospho-proteomics, Inhibition